Pharmacodynamics

Exposure-Response

“What the drug does to the body”

Table 1: Pharmacodynamic symbols

Symbol	Description
E	Effect
I	Inhibition
EC50	Concentration for half of maximum effect
IC50	Concentration for half of maximum inhibition
Emax	Theoretical max effect
Imax	Theoretical max inhibition

Drug effect models

$$\mathrm{E}=\frac{{\mathrm{E}}_{\max }\times {\mathrm{C}}^{\gamma }}{{\mathrm{C}}^{\gamma }+{\mathrm{EC}}_{50}^{\gamma }}$$

$$\mathrm{E}={\mathrm{E}}_0-\mathrm{slope}\times t$$

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