Pharmacodynamics
Exposure-Response
“What the drug does to the body”
| Symbol | Description |
|---|---|
| E | Effect |
| I | Inhibition |
| EC50 | Concentration for half of maximum effect |
| IC50 | Concentration for half of maximum inhibition |
| Emax | Theoretical max effect |
| Imax | Theoretical max inhibition |
Drug effect models
\[ \mathrm{E} = \frac{ \mathrm{E_max} \times \C^\gamma }{ \C^\gamma + \mathrm{EC}^\gamma_{50} } \]
\[ \mathrm{E} = \mathrm{E_0} - \mathrm{slope} \times t \]
(1-compartment)