Pharmacodynamic (response) modeling

Q: What is pharmacometrics?

Pharmacometrics is the science of quantitative pharmacology that uses mathematical models to describe and predict drug behavior in patients. It combines pharmacokinetics (what the body does to the drug) and pharmacodynamics (what the drug does to the body) to optimize drug development and dosing.

Q: What is NONMEM used for?

NONMEM (NONlinear Mixed Effects Modeling) is specialized software for population pharmacokinetic/pharmacodynamic modeling. It's used to analyze drug concentration-time data from clinical trials to understand variability between patients and optimize dosing regimens.

Q: How is pharmacometrics used in drug development?

Pharmacometrics supports drug development by predicting optimal doses, identifying patient populations likely to benefit, designing efficient clinical trials, and supporting regulatory submissions with quantitative evidence of drug efficacy and safety.

Published

August 24, 2025

Under construction

Pharmacodynamic (response) modeling

Types of responses

References