NONMEM Tips-n-Tricks
Under construction
Introduction
NONMEM is a computer program. The name stands for “NONlinear Mixed Effects Modeling.”
https://www.iconplc.com/solutions/technologies/nonmem
Some gotchas for NONMEM:
- Machine (double) precision:
MEPS = 1.0E-15
INFTY = 1.0E+154
- Largest possible integer =
2147483647
Running NONMEM
- NONMEM places the low bound equal to 1/100 (or 1/1000) of the initial value even if it is set to zero in the code. You may rerun with lower initial value or put
NOTHETABOUNDTEST
to the estimation record. (Credit: Leonid Gibiansky)
Faster parallel NONMEM
--threads-per-core=1
: Do not hyperthread.
FILE07–39
should be size 0; in fact, FILE*
should be size 0. Therefore, use --maxlim=3
: Do not use diskspace (slow).
Interactive control of NONMEM runs
Find the directory where NONMEM is running (NM_run1/
in PsN) and manually create an empty file with a different name according to the desired action.
Here’s a list:
Action | Description | Filename |
---|---|---|
Print toggle | Monitor estimation progress | print.sig |
Paraprint toggle | Monitor parallel processing traffic | paraprint.sig |
Next | Move on to next estimation mode or next estimation. NONMEM grinds a couple of iterations more and then it terminates nicely as if the maximum number of function evaluations had been reached. | next.sig |
Stop | End the present run cleanly | stop.sig |
Subject print toggle | subject.sig |