Pediatrics

Age groups:

• 0-2 years
• 3-6 years
• 7-12 years
• 13-17 years (adolescents)
• 18+ years (adults)

Renal maturation (Rhodin et al. 2009)[https://doi.org/10.1007/s00467-008-0997-5]:

maturation = PMAHill / (TM_50Hill + PMA**Hill)

The maturation half-life (TM_50) is fixed to the literature value of 47.7 weeks and the Hill exponent to the value of 3.4 (both from Rhodin et al.). The distribution (mean, [min-max]) of PMA (weeks) in this study population was (518, [57-1652]). Assuming that the time to reach 50% of the maximum renal maturation could be different in pre-term infants, a different value for TM_50 could be estimated for pre-term neonates, if the current model does not describes this sub-group well.